Our primary research objective is to develop novel methods of drug delivery in order to provide patient-friendly and easy-to-use means of disease management. Development of novel drug delivery methods is contingent upon our ability to control the transport of desired bio-molecules in the tissues against the naturally exerted forces by tissues arising form steric, chemical, and physical interactions of bio-molecules with the tissues. By developing a fundamental understanding of such transport processes, we seek to develop novel strategies involving the use of external forces (ultrasound, chemicals, and high velocity jets) as well as newly fabricated biomaterials with advanced structure-function characteristics for applications in drug delivery.