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Precision molecular recognition underlies the circuitry of complex biological systems. Current research in my laboratory aims to elucidate protein interaction principles in biological systems, and to develop and apply methods and technologies for the diagnosis and treatment of human disease. We have developed several new technologies that enable i) isolation and engineering of protein-binding ligands with improved affinity and specificity, ii) semi-automated affinity ligand isolation using micro-fluidic cell sorters, iii) intracellular sensing and screening for enzyme activity and protein interactions, and iv) engineering and characterization of peptidases. These new biotechnologies create significant opportunities to apply molecular and cellular engineering to improve human health. In particular, we are applying these tools to develop advanced medical diagnostic technologies, and novel therapeutic approaches that rely upon engineered molecular machines and artificial signal transduction systems. Our work is highly interdisciplinary and benefits from several active collaborations with academic and industrial laboratories, and physicians.
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